منابع مشابه
Levels and distribution of BCNU in GBM tumors following intratumoral injection of DTI-015 (BCNU-ethanol).
The alkylation products formed by in vitro treatment of DNA with tritium-labeled 1,3-bis(2-chloroethyl)-1-nitrosourea ((3)H-BCNU) were identified and quantified. Twelve adducts were resolved by high-performance liquid chromatography (HPLC). The principal DNA adducts formed by BCNU treatment corresponded to N-7-(2-hydroxyethyl)guanine (N7-HOEtG) (26%), N-7-(2-chloroethyl)guanine (15%), and phosp...
متن کاملTherapeutic efficacy of DTI-015 using diffusion magnetic resonance imaging as an early surrogate marker.
To investigate diffusion weighted magnetic resonance imaging as a quantitative surrogate marker for evaluating the therapy-induced cellular changes in an orthotopic experimental glioma model, tumors were treated with direct intratumoral administration of DTI-015, a solution of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in 100% EtOH. Intracerebral 9L tumors were induced in Fischer 344 rats, and...
متن کاملRecurrent Gliosarcoma in Pregnancy
Gliosarcoma is a rare tumor of the central nervous system and it constitutes about 1 to 8% of all malignant gliomas. In this report we are presenting a recurrent gliosarcoma case during a pregnancy in a 30-year-old woman. This is the first report presenting gliosarcoma in the pregnancy.
متن کاملInfantile gliosarcoma.
Dr. José Roberto Tude Melo – HUPES/UFBA Rua Augusto Viana sn / 2° andar 40110-060 Salvador BA Brasil. E-mail: [email protected] Since the first reports published by Stroebe in 1895, more than 100 cases of gliosarcoma have been reported, eight of which were in children. Gliosarcoma accounts for 1.8 to 8% of all glioblastomas. It is classified by the World Health Organization (WHO) as a grade I...
متن کاملCongenital malignant gliosarcoma.
Malignant gliosarcoma is an extremely rare, anaplastic tumor which to date has been found exclusively in adults. This type of sarcoma is a form of mixed glioma and sarcoma which is quite different and distinct from the type of sarcoma that arises in a glioblastoma [1]. Less than 10 cases of this entity have been reported [2-5]. We report a case of this unusual tumor in a 4-month-old girl who ha...
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ژورنال
عنوان ژورنال: Neoplasia
سال: 2003
ISSN: 1476-5586
DOI: 10.1016/s1476-5586(03)80013-1